Dr Nick Kassouf is the Technical Tutor for Biomedical Science within the Department of Natural Sciences, since 2015.
He completed his PhD in oral oncology and apoptosis at Queen Mary, University of London in 2005 and soon after worked as a post-doctoral research fellow in the Cardiovascular Division at King's College London, investigating human platelet signalling pathways.
Following this position he took up the post of post-doctoral research associate at Imperial College London in 2008 working on a EU FP7 collaborative funded project to elucidate the role of KAI1, a metastasis suppressor and dependence receptor, in various cancer cell lines.
In 2010, Nick took up a post-doctoral research scientist position at The RAFT Institute working on a CRUK project involved in investigating the free radical-induced damage caused by UVA irradiation in melanomas and melanocyte cells with varying melanin content and DNA repair proteins.
In 2013 Nick became a senior research fellow at the University of Hertfordshire investigating skin dermal absorption and mass decontamination studies.
BSc, MSc, PhD, PGCertHE
English, Arabic, French (basic)
Learning & Teaching Interests
Nick is currently teaching on the Biomedical Foundation course as well as Biology/Biomedical undergraduate courses:
Molecular and Genetic Sciences
Molecular and Cellular Pathology
Research Outputs & Interests
My main research interests are as follows:
Oxidative stress, melanin and DNA repair mechanisms in melanoma and skin cells, when exposed to UV irradiation, using a novel electron spin resonance (ESR) model.
Investigating a novel non-invasive method to detect bacterial-induced skin damage.
Investigating combination therapy of natural products and chemotherapy agents on myeloid leukaemias and relevant mechanisms of action.
The role of specific apoptosis pathways in cancer cell mediated immune cell death.
Chiang, Shih-Chieh and Meagher, Martin and Kassouf, Nick and Hafezparast, Majid and McKinnon, Peter and Haywood, Rachel and El-Khamisy, Sherif (2017) Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. Science Advances, 3 (4). ISSN 2375-2548
Kassouf, Nick and Syed, Sara and Larner, Joanne and Amlot, Richard and Chilcott, Robert (2017) Evaluation of absorbent materials for use as ad hoc dry decontaminants during mass casualty incidents as part of the UK's Initial Operational Response (IOR). PLoS One . ISSN 1932-6203
Haywood, Rachel and Andrady, Carima and Kassouf, Nick and Sheppard, Nick (2011) Intensity-dependent direct solar radiation- and UVA-induced radical damage to human skin and DNA, lipids and proteins. Photochemistry and Photobiology, 87 (1). pp. 117-130. ISSN 0031-8655
Kassouf, Nick and Ambily, Archana and Watson, Stephanie and Hassock, Sheila and Authi, Harmeet S. and Srivastava, Salil and Watson, Steve P. and Authi, Kalwant S. (2015) Phosphatidylinositol-3,4,5-trisphosphate stimulates Ca2+ elevation and Akt phosphorylation to constitute a major mechanism of thromboxane A2 formation in human platelets. Cellular Signalling, 27 (7). pp. 1488-1498. ISSN 0898-6568
Ambily, A. and Kaiser, W. J. and Pierro, C. and Chamberlain, E. V. and Li, Z. and Jones, C. I. and Kassouf, Nick and Gibbins, J. M. and Authi, K. S. (2014) The role of plasma membrane STIM1 and Ca2+entry in platelet aggregation. STIM1 binds to novel proteins in human platelets. Cellular Signalling, 26 (3). pp. 502-511. ISSN 0898-6568