Organic Chemistry, Pharmaceutical Chemistry, Biochemistry, Analytical methods, Innovation in Biosciences
My research interests fall at the interface of chemistry and biology focusing on studies of bioactive molecules including, synthesis, interactions with biomolecules and drug delivery. The focus of my PhD thesis was the multistep synthesis of natural products (azaspiracid-3) and molecular recognition studies of barbiturates. As a postdoctoral researcher, I studied the resistance mechanisms of HIV-1 integrase inhibitors and revealed a two-way binding mode of the first FDA approved integrase inhibitor, raltegravir. The results of this study received the first award at the 7th European HIV Drug Resistance Workshop and published in Biochemistry as a rapid report that was characterised as one of the 10 most accessed rapid reports in 2009. I later became interested in the human proteasome and developed a computational protocol to study the factors that confer subunit selectivity to proteasome inhibitors and opened the prospect of collaboration with pharmaceutical companies. A current research project includes the evaluation of argyrin analogues as inhibitors of the proteasome and immunoproteasome by using molecular modelling and in vitro assays.
Another research area of interest is the transdermal delivery of highly potent therapeutics using microneedles. This project involves an exploration of microfabrication techniques for the preparation of microneedles, imaging techniques for evaluating skin penetration, drug delivery studies and finite element analyses for the structural characterization of the microneedles.
Peer-reviewed publication list:
Refereed articles in Academic Journals:
Refereed and published conference proceedings:
Books chapters and Dissertations:
Loizidou, Erika and Inoue, Nicholas T. and Ashton-Barnett, Johnny and Barrow, David A. and Allender, Chris J. (2016) Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis. European Journal of Pharmaceutics and Biopharmaceutics, 107 . pp. 1-6. ISSN 0939-6411
Loizidou, Erika and Williams, Nicholas. A. and Barrow, David A. and Eaton, Mark J. and McCrory, John and Evans, Sam L. and Allender, Chris J. (2015) Structural characterization and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses. European Journal of Pharmaceutics and Biopharmaceutics, 89 . pp. 224-231. ISSN 0939-6411
Loizidou, Erika and Haralambous, D. and Vamvakaki, M. and Patrickios, C. S. and Krasia, T. and Antonietti, M. (2001) AB diblock and ABC triblock amphiphilic copolymers containing fluorine. In: 221th ACS National Meeting, 01 Apr 2001, San Diego, CA, USA.
Loizidou, Erika and Zhang, K. and Sun, L. (2002) Characterization of amphiphilic polymers covalently attached with Pirkle-concept chiral selectors for chiral seperations by Merck. In: 224th ACS National Meeting, 18 Aug 2002.
Loizidou, Erika and Sun, L. (2003) Molecular recognition of barbiturate artificial receptor covalently bound to an amphiphilic copolymer. In: International Symposium on the Synthesis and Characterization of Macromolecules, 07-11 Feb 2003, Amsterdam, Netherlands.