Dr Lucy R. Ghali
Ghali L and Dyson M. The effect of light therapy on endothelial cell proliferation in vitro (1992). Angiogenesis: Key Principles- Science “ technology “ Medicine. Ed by R. Steiner, P.B. Weisz & R Langer. Birkhuser Verlag Basel / Switzerland.
Peer reviewed Journal Articles
X Wen, D Li, Y Zhang, S Liu, L Ghali, RK Iles (2012). Arsenic trioxide induces cervical cancer apoptosis but specifically targets Human Papillomavirus infected cell populations. Anti-Cancer Drugs. 23: 280–287.
Nadendla SK, Hazan A, Ward M, Harper LJ, Moutasim K, Bianchi LS, Naase M, Ghali L, Thomas GJ, Prowse DM, Philpott MP, Neill GW. GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state. PLoS One. 2011;6(5):e20271. Epub 2011 May 25.
Xuesong Wen, Dong Li, Lucy Ghali, and Ray K Iles. (2010) Ectopic HCG beta may induce epithelialmensenchymal transition on human keratinocytes in vitro and this could promote tumour progression and invasion. Tumour Biology, 31 (S44). ISSN 1010-4283 (abstract)
Papadakis ES, Cichoń MA, Vyas JJ, Patel N, Ghali L, Cerio R, Storey A, O'Toole EA. Axl Promotes Cutaneous Squamous Cell Carcinoma Survival through Negative Regulation of Pro-Apoptotic Bcl-2 Family Members. J Invest Dermatol. 2011 Feb;131(2):509-17. Epub 2010 Nov 11
Ellis PE, Cano SD, Fear M, Kelsell DP, Ghali L, Crow JC, Perrett CW, MacLean AB. Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast. Mod Pathol. 2008 Oct;21(10):1192-9. Epub 2008 May 9
Dong Li, Xuesong Wen, Lucy Ghali , FM Al-Shalabi, Suzanne M Docherty, Patricia Purkis, Ray K Iles. hCG-β expression by cervical squamous carcinoma- in vivo histological association with tumour invasion and apoptosis. Histopathology. 2008 Aug;53(2):147-55.
Neill GW, Harrison WJ, Ikram MS, Williams TD, Bianchi LS, Nadendla SK, Green JL, Ghali L, Frischauf AM, Edel O, Aberger F, Philpott MP. GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes. Carcinogenesis. 2008 Apr;29(4):738-46.
Das M, Djahanbakhch O, Hacihanefioglu B, Saridogan E, Ikram M, Ghali L, Raveendran M, Storey A. Granulosa cell survival and proliferation are altered in Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2007 Dec 11 [Epub ahead of print]
Akgül B, Ghali L, Davies D, Pfister H, Leigh IM, Storey A.HPV8 early genes modulate differentiation and cell cycle of primary human adult keratinocytes. Exp Dermatol. 2007 Jul;16(7):590-9.
Golder M, Burleigh DE, Ghali L, Feakins RM, Lunniss PJ, Williams NS, Navsaria HA.Longitudinal muscle shows abnormal relaxation responses to nitric oxide and contains altered levels of NOS1 and elastin in uncomplicated diverticular disease. Colorectal Dis. 2007 Mar;9(3):218-28.
Teh MT, Blaydon D, Ghali L, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP, Philpott MP. Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci. 2007 Jan 15; 120(Pt 2):330-9. Epub 2007 Jan 2
Leverrier S, Bergamaschi D, Ghali L, Ola A, Warnes G, Akgul B, Blight K, Garcia-cudero R, Penna A, Eddaoudi A, Storey A. Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Apoptosis. 2006 Dec 31; [Epub ahead of print]
Thwaini A, Naase M, Chinegwundoh F, Baithun S, Ghali L, Shergill I, Iles R. Gonadotropins and prostate cancer: revisited. Urol Int. 2006;77(4):289-96
Green J, Ikram M, Vyas J, Patel N, Proby CM, Ghali L, Leigh IM, O'toole EA, Storey A. Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. Br J Cancer. 2006 Apr 25; [Epub ahead of print]
Brown VL, Atkins CL, Ghali L, Cerio R, Harwood CA, Proby CM. Safety and efficacy of 5% Imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial. Arch Dermatol. 2005 Aug;(8):985-93
Akgul B, Garcia-Escudero R, Ghali L, Pfister HJ, Fuchs PG, Navsaria H, Storey A. The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Cancer Res. 2005 Mar 15;65(6):2216-23.
Ong C, O'Toole EA, Ghali L, Malone M, Smith VV, Callard R, Harper JI. LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome. Br J Dermatol. 2004 Dec;151(6):1253-7.
Ghali L, Wong ST, Tidman N, Quinn A, Philpott MP, Leigh IM. Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulphate proteoglycan core protein. J Invest Dermatol. 2004 Feb;122(2):433-42.
Neill GW, Ghali LR, Ikram MS, Philpott MP, Quinn AG. Loss of protein kinase C alpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. Cancer Res. 2003 Aug 1;63(15):4692-7.
Mark Golder, david E Burleigh, Abi Belai, Lucy Ghali, Deborah Ashby, Peter Lunniss, Harry A Navsaria, Norman S Williams. Smooth muscle cholinergic denervation hypersensitivity in diverticular disease. The Lancet. Vol 361. June 7, 2003.
B. K. Bloor, N. Tidman, I.M. Leigh, E. Odell, B. Dogan, W. Wollina, L.Ghali and A. Waseem. Expression of keratin K2e in cutaneous and oral lesions, Association with keratinocyte Activation, proliferation, and keratinisation American J. Path. Vol 162 No3, March 2003
Teh MT, Wong ST, Neil GW, Ghali LR, Philpott MP. Quinn AG. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res. 2002 Aug 5;62 (16):4773-80.
Jackson S, Ghali L, Harwood C, Storey. Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with dedection of cutaneous human papillomavirus. Br J Cancer 2002 July29;87(3):319-23
Chronnell CM, Ghali LR, Ali RS, Quinn AG, Holland DB, Bull JJ, Cunliffe WJ, McKay IA, PhilpottMP, Muller RoverS. Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. Journal of Investigative Dermatology. 2001: Nov;117(5):1120-5. PMID: 11710922
Ghali L, Wong ST, Green J, Tidman N, Quinn AG. Gli1 protein is expressed in Basal Cell Carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. J Invest Dermatol. 1999 Oct; 113 (4):595-9. PMID: 10504446; UI: 99436242
Catherine A. Harood, Victoria J. Swale, Veronique A. Bataille, Anthony G. Quinn, Lucy Ghali, Sejal V. Patel, Isis Dove-Edwin and Jane M. McGregor. An Association Between Sebaceous Carcinoma and Microsatellite Instability in Immunsuppresed Organ Transplant Recipients. J Invest Dermatol. 2001 Feb; 116(2): 246-253.
Agaiby A, Ghali L and Mary Dyson M. Laser modulation of T-Lymphocyte proliferation in vitro. Lasers Surg Med 2000; 26 (4): 357-63. PMID: 10805940, UI: 20266256 Purkayastha PD, Agaiby A, Ghali L, and Mary Dyson. Cell adhesion molecule expression in wounds of diabetic and non-diabetic rats. Diabetes, Vol. 46: June 1997.
External lectures as an Invited Speaker
- Poster prize winner 20th International Papillomavirus conference, Paris Oct 4-9 2002. HPV5 and 18 E6 Proteins interfere with the release of apoptosis inducing factor (AIF) from mitochondria
- Oral Presentation European Keratinocyte association meeting, Maastricht 2002. Expression of Keratin K2e in cutaneous and oral lesions, Association with keratinocyte Activation, proliferation and keratinisation
- Reviewer for the medical Journal Gut
- Cell Biology and cell culture
- Histology and Dermatology
- Cancer cell biology
- Pathology Laboratory skills
- Human Pathology
- Cell cycle control
- Cancer Biomarkers
- The genetics of HPV induced cancers
- Skin cancers
- hCGbeta;'s role in tumour invasion and angigenesis
- Cell cycle marker detection during oncogenesis
- The pathology of uro-genital cancers