Professor Ivan M. Roitt

Director, Centre for Investigative & Diagnostic Oncology

Department: School of Health and Social Sciences

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Qualifications

1949-53                  B.A./D.Phil. - Chemistry       

1953                        B.A. (Hons) - Physiology    

1968                        D.Sc. (Oxford)

1974                        F.R.C. Path.


1983                        Elected Fellow of The Royal Society, London

Research Interests

Cancer imaging and therapies based upon nanoparticle technology

Diagnostic protein microarrays

Dyslexic diagnosis

Teaching Interests

Immunology in Microbiology

Biography

1968-1992:  Head of Departments of Immunology & Rheumatology Research, University College Medical School, London.

1992-2009:  Emeritus Professor of Immunology, University College London

 

Curriculum/subject area

Microbiology (infectious disease)

Current work administrative and professional duties/roles

Directing Cancer Research Institute

Assistant Coordinator, EU Consortium on Vaginal HIV Microbicides

Elected to Council of the Royal Society of Medicine, London.

Research

Selected publications:

A human domain antibody and Lewis b glycoconjugate that inhibit binding of Helicobacter pylori to Lewis b receptor and adhesion to human gastric epithelium.Younson J., O’Mahony R., Liu H., Grant S., Campion C., Vaira D., Jennings L, Kelly CG., Roitt I.M. & Holton J.  J. Infect. Dis. (2009) 200, 1574-82.

  • Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray that uses a filtration-assisted Nanodot Array Luminometric Immunoassay (NALIA). McBride JD, Gabriel FG, Fordham J, Kolind T, Barcenas-Morales G, Isenberg DA, Swana M, Delves PJ, Lund T, Cree IA, Roitt IM. Clinical Chemistry (2008) 54:5, 883-90.
  • Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. De Bernardis F., Liu H., O'Mahony R., La Valle R., Bartollino S., Sandini S., Grant S., Brewis N., Tomlinson I., Basset C., Holton J., Roitt I.M., Cassone A. J. Infect. Dis. (2007), 195, 149-157.
  • Vaccines for the control of reproduction - status in mammals, and aspects of comparative interest. Roitt IM, Delves PJ. Fish Vaccinology. Dev. Biol. Basel, Karger (2005), 121, 265-273.
  • The hCG beta arginine68 to glutamic acid substitution fixes the conformation of the C-terminal peptide. Charrel-Dennis M, Terrazzi N, McBride J, Martnsen P, Justensen J, Berger P, Lapthorn A, Kelly C, Roitt IM, Delves PJ, Lund T. Mol. Endocrinol. (2005) 19(7), 1803-1811.
  • Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy. O'Mahony R., Basset C., Holton J., Vaira D. Roitt I. J. Microbiol. Methods (2005) 61, 105-126. UK Patent Application No: 0411381.7 Assay method and apparatus.
  • Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70. Hannesdottir SG, Han X, Lund T, Singh M, van der Zee R., Roitt IM, Delves PJ. Reproduction (2004) 128, 365-371.
  • The major hormone-specific discontinuous epitopes on human chorionic gonadotropin. Charrel-Dennis M, Jackson AM, Lund T, Lapthorn AJ, Berger P, Roitt IM and Delves PJ. Journal of Molecular Endocrinology (2004) 32, 571-581.
  • Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2. A. Safwat, N. Aggerholm, I. Roitt, J. Overgaard and M. Hokland: E. J. Cancer, 40(9):1412-7, 2004.
  • Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma. Safwat A., Aggerholm N., Roitt I., Overgaard J. Hokland M. J. Exp. Therapeutics Oncology (2004) 3, 161-168.

Co-authored books

  • 'Roitt's Essential Immunology' (11th edition), 2006, Blackwells Publishing
  • 'Immunology' (7th edition), 2006, Mosby
  • 'Medical Microbiology' (4th edition) 2008, Elsevier/Mosby.

Recent conferences - N/A

Honours Prizes

  • Van Meter Prize, American Goitre Association1957
  • Gairdner Award (Toronto)1964
  • Awarded Medal for Discovery of Thyroid Autoimmunity from Pisa University, Italy.1986
  • Elected Fellow of The Royal Society, London1983
  • Hon. Fellowship, Royal Society of Medicine, London 1993
  • Hon. Fellowship, Royal College of Physicians, London 1995
  • Hon. Fellowship, Balliol College, Oxford 2005

Links with Business Organisations

  • Chief Scientist, NALIA Systems Ltd
  • Scientific Advisory Board: Pepscan Ltd., The Netherlands.
  • Consultant: Midatech Ltd., U.K.
  • Consultant: Ablynx, Belgium
  • Consultant: DDC, USA.
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