Professor Ray Iles

Associate Dean- Research

Department: School of Health and Social Sciences

Contact

Qualifications

BSc, MSc, PhD, CBiol MIBiol FRSC

Research Interests

Cancer Biomarkers

  • Ectopic hCGbeta; expression by urogenital tumours
  • Placental Alkaline Phosphatase
  • Bone metabolism markers in screening for metastatic spread
  • Anti- hCGbeta; cancer vaccines
  • Population screening and prevalence of an LH glycovariant in prostate cancer
  • MALDI - TOF glyco-proteomics

Obstetric care

  • Early Biochemical detection of ectopic pregnancy
  • Downs Syndrome Screening

Teaching Interests

  • Oncology and tumour marker biology
  • Reproductive biology, Obstetrics and Gynaecology
  • Cell Biology
  • Basic and applied Molecular Biology Techniques
  • Biochemistry techniques
  • Proteomics
  • Transferable skills for graduate researchers
  • Statistics and data analysis

Biography

Recent Publications/ Seminars

Book chapters

  • R.K.Iles. Cell molecular biology and genetics disorders. In: Clinical Medicine 7th Edition. Ed: P. Kumar and M. Clark Elsevier Health Sciences, Edinburgh (2009)
  • R.K. Iles. Chapter 1 Basic Sciences - The Cell. In: Urological Oncology Ed. V. H. Nargund D. Raghavan and H.M Sandler Springer-Verlag London (2007) pp3-36 ISBN 978-1-84628-87-1
  • R.K.Iles. Cell molecular biology and genetics disorders. In: Clinical Medicine 6th Edition. Ed: P. Kumar and M. Clark Elsevier Health Sciences, Edinburgh (2005) pp153-190
  • C.M.R. Bax, S. Davies, E. Chatzaki, S.A. Butler R.K.Iles. The role of glycoprotein hormones in endometrial cancer. In: Cell and Molecular Biology of Endometrial Carcinoma. Eds H. Kuramoto, Springer-Verlag Tokyo (2003) Part 7 Hormones Hormone Receptor pp 195- 206.
  • R.K.Iles. Cell molecular biology and genetics disorders. In: Clinical Medicine 5th Edition. Ed: P. Kumar and M. Clark Harcourt Health Sciences, Edinburgh (2002) pp153-191.
    Peer reviewed research papers
  • Li D, Wen X, Ghali L, Al-Shalabi FM, Docherty SM, Purkis P, Iles RK. hCG beta expression by cervical squamous carcinoma--in vivo histological association with tumour invasion and apoptosis.Histopathology. (2008) 53: 147-55.
  • Kassanos P, Iles RK, Bayford RH Desmosthenous A. Towards the development of an electrochemical biosensor for hCGB detection. Physiological Measurements, (2008) 29:S241-54
  • Wen X, Tozer AJ, Li D, Docherty SM, Al-Shawaf T, Iles RK. Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte. Fertil Steril. (2008), 89: 1406-1413.
  • Kicman AT, Parkin MC, Iles RK. An introduction to mass spectrometry based proteomics-detection and characterization of gonadotropins and related molecules. Mol Cell Endocrinol. (2007) 260-262:212-27.
  • Iles RK. Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis. Mol Cell Endocrinol. (2007) 260-262:264-70.
  • Delves PJ, Iles RK, Roitt IM, Lund T. Designing a new generation of anti-hCG vaccines for cancer therapy. Mol Cell Endocrinol. (2007) 260-262:276-81.
  • Thwaini A, Naase M, Chinegwundoh F, Baithun S, Ghali L, Shergill I, Iles R. Gonadotropins and prostate cancer: revisited. Urol Int. (2006 )77:289-96.
  • Wen X., Tozer A.J., Butler S.A., Bell C.M., Docherty S.M., Iles RK. Follicular fluid levels of inhibin A, inhibin B and activin A levels reflect changes in follicle size but are not independent markers of oocyte ability to fertilize. Fertility and Sterility (2006) 85:1723-1729.
  • Otite U, Baithun S, Chinegwundoh F, Nargund VH, Iles RK. Detection of human chorionic gonadotrophin-beta in serum or urine of prostate cancer patients is of no clinical significance. Tumour Biol. 2006;27(4):181-6.
  • Wen X, Tozer AJ, Butler SA, Bell CM, Docherty SM, Iles RK. Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize. Fertil Steril. 2006 Jun;85(6):1723-9.
  • Thurairaja R, Iles RK, Jefferson K, McFarlane JP, Persad RA. Serum amino-terminal propeptide of type 1 procollagen (P1NP) in prostate cancer: a potential predictor of bone metastases and prognosticator for disease progression and survival. Urol Int. 2006;76(1):67-71.
  • Malatos S, Neubert H, Kicman AT, Iles RK. Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques.Mol Cell Proteomics. 2005 Jul;4(7):984-92.
  • Tozer AJ, Iles RK, Iammarrone E, Nica RA, Gillott CM, Xusong W, Al-Shawaf T, Grudzinskas JG. Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF. Hum Reprod. 2004 Nov;19(11):2561-8.
  • Butler SA, Iles RK. The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects. Tumour Biol. 2004 Jan-Apr;25(1-2):18-23.
  • Tozer AJ, Iles RK, Iammarrone E, Gillott CM, Al-Shawaf T, Grudzinskas JG. The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome. Hum Reprod. 2004 Mar;19(3):522-8.
  • Butler SA, Staite EM, Iles RK. Reduction of bladder cancer cell growth in response to hCGbeta CTP37 vaccinated mouse serum. Oncol Res. 2003;14(2):93-100.
  • Borrelli PT, Butler SA, Docherty SM, Staite EM, Borrelli AL, Iles RK. Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy. Clin Chem. 2003 Dec;49(12):2045-9.
  • Butler SA, Iles RK. Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? Clin Cancer Res. 2003 Oct 15;9(13):4666-73. Review.
  • Jacoby ES, Kicman AT, Iles RK. Identification of post-translational modifications resulting from Lhbeta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LHbeta core fragment. J Mol Endocrinol. 2003 Apr;30(2):239-52.
  • Neubert H, Jacoby ES, Bansal SS, Iles RK, Cowan DA, Kicman AT. Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G. Anal Chem. 2002 Aug 1;74(15):3677-83.
  • Hamilton JA, Iles RK, Gunn LK, Wilson CM, Lower AM, Grudzinskas JG. High concentrations of CA 125 in uterine flushings: influence of cause of infertility and menstrual cycle day. Gynecol Endocrinol. 2002 Feb;16(1):19-25.
  • Stewart CJ, Iles RK, Perrett D. The analysis of human amniotic fluid using capillary electrophoresis. Electrophoresis. 2001 Apr;22(6):1136-42.

External lectures as an Invited Speaker

  • 11th December 2008. When does human Life begin? London Health 2008 Conference, Business Design Centre Islington, London UK
  • 6th July 2008. What role does hCG play in Cancer? Plenary Lecture - International Conference on Gonadotropins and Receptor (ICGRII), Theobald Park Hertfordshire UK
  • 24th May 2006. Gonadotropin Gyco-fingerprinting.. The Future of Preparation, Detection and Data Processing For Chromatography and 50th Anniversary AGM of the Chromatographic Society, The Schimadzu RD Centre, Milton Keynes, UK
  • 6th April 2006. Does perineural invasion result in early bone metastasis in prostate cancer? Annual Conference, European Association of Urology, Paris, France
  • 6th April 2006. Using prostate-specific antigen (PSA) and amino-terminal propeptide of type 1 procollagen (P1NP) with axial skeletal magnetic resonance imaging (MRI) enhances prediction and detection of early bone metastases in prostate cancer. Annual Conference, European Association of Urology, Paris, France
  • 17th April 2005. The role of hCG� in the oncogenesis in particular invasion and metastasis relevance to cancer vaccine development. International Meeting on Gonadotropins and receptors. University of Atlanta, Athens, Georgia, USA
  • 16th April 2005. Free beta-hCG modulates epithelial tumor cell growth by inhibition of apoptosis International Meeting on Gonadotropins and receptors. University of Atlanta, Athens, Georgia, USA
  • 15th April 2005. Gonadotropin Glyco-fingerprinting by MALDI-TOF Mass Spectrometry. International Meeting on Gonadotropins and receptors. University of Atlanta, Athens, Geogia USA
  • 20th June 2004. Ectopic expression of free hCG�, a marker of poor prognosis. ISOBM 2004 Helsinki meeting
  • 4th November 2003. Improving the early diagnosis of ectopic pregnancy, The UK Gynaecologist Travellers Society, London meeting 2003.
  • 27th September 2003. Biochemical diagnosis of prostate bone metastasis. ISOBM 2003 Edinburgh meeting.
  • 25th July 2001. Biochemical changes in pregnancy associated with a Down's syndrome fetus. Department of Obstetrics Gynaecology, University of New Mexico, USA.
  • 26th January 2001. New developments in tumour marker technology. International Valedictory meeting to celebrate the work of Professor Tim Chard - London

External Institutions

  • Visiting Professor in Forensic Science and Drug Monitoring, Kings College London
  • Honorary Professor in Biomedical Science, London Metropolitan University
  • Member of the MRC College of experts
  • Grant Assessor for the Singapore National Medical Research Council
  • Grant assessor for the Hong Kong Government Medical Research Council
  • Scientific assessor for The National Lotteries Charities Board
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