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      Prof Andreas Albrecht

      ROLE: Professor in Simulation & Modelling
      SCHOOL: Science & Technology
      DEPARTMENT: Computer Science
      TELEPHONE: +44 (0)20 8411 5577
      EMAIL: A.Albrecht@mdx.ac.uk
      1. Biography &
        Qualifications
      2. Learning &
        Teaching Interests
      3. Research Outputs &
        Interests
      4. Funded Research &
        Knowledge Exchange Projects
      5. Engagement &
        Impact

      • Biography &
        Qualifications

        Qualifications:

        BSc+MSc in Computational Mathematics (MSU); PhD (Dr.rer.nat, HUB); Dr.sc.nat. (HUB); facultas docendi (HUB).

        Selected recent publications:

        • Lataniotis/Albrecht/Kok/Monfries/Benedetti/Lawson/Hughes/Steinhofel/Mayr/Zampetaki: CRISPR/Cas9 gene editing highlights the prominent role of structure in noncoding RNA function: The case of clustered MicroRNAs in the vasculature. Circulation, 136:A18034, 2017.
        • Lataniotis/Albrecht/Kok/Monfries/Benedetti/Lawson/Hughes/Steinhofel/Mayr/Zampetaki: Crispr/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Scientific Reports, 7:8585, 2017.
        • Lataniotis/Albrecht/Kok/Monfries/Benedetti/Lawson/Hughes/Steinhofel/Mayr/Zampetaki: Crispr/Cas9 gene editing reveals novel tertiary constraints in clustered miRNA processing. Heart, 103:A133, 2017.
        • Day/Abdelhadi Ep Souki/Albrecht/Steinhofel: Random vs deterministic descent in RNA energy landscape analysis. Advances in Bioinfromatics, 9654921, 2016.
        • Albrecht/Day/Abdelhadi Ep Souki/Steinhofel: A new heuristic method for approximating the number of local minima in RNA energy landscapes. Computational Biology and Chemistry, 60:43-52, 2016.
        • Lai/Albrecht/Steinhofel: iRDA: a new filter towards predictive, stable, and enriched candidate genes. BMC Genomics, 16:1041, 2015.
        • Lai/Otzturk/Albrecht/Steinhofel: A new vision of evaluating gene expression signatures. Computational Biology and Chemistry, 57:54-60, 2015.
        • Day/Abdelhadi Ep Souki/Albrecht/Steinhofel: Accessibility of microRNA binding sites in meta-stable RNA secondary structures in the presence of SNPs. Bioinformatics, 30(3):343-352, 2014.
        • Maher/Albrecht/Loomes/Yang/Steinhofel. A Firefly-inspired method for protein structure prediction in lattice models. Biomolecules, 4(1):56-75, 2014.
        • Lai/Albrecht/Steinhofel. Gene selection guided by feature interdependence. WASET, 79:1432-1438, 2013.
        • Sahoo/Albrecht: Approximating the set of local minima in partial RNA folding landscapes. Bioinformatics, 28:523–530, 2012.
        • Ullah/Sahoo/Steinhofel/Albrecht: Derivative scores from site accessibility and ranking of miRNA target predictions. Int J Bioinformatics Research and Applications, 8:171-191, 2012.
        • Sahoo/Albrecht: Ranking of microRNA target prediction scores by Pareto front analysis. Computational Biology and Chemistry, 34:284–292, 2010.
        • Albrecht/Lane/Steinhofel: Analysis of local search landscapes for k-SAT instances. Mathematics in Computer Science, 3:465–488, 2010.
        • Albrecht/Kapsokalivas/Steinhofel: Uphill unfolding of native protein conformations in cubic lattices. Journal of Computational Science, 1:6–12, 2010.
        • Albrecht/Chashkin/Iliopoulos/Kasim-Zade/Lappas/Steinhofel: A note on a priori estimations of classification circuit complexity. Fundamenta Informaticae, 104:1-17, 2010.
        • Kapsokalivas/Gan/Albrecht/Steinhofel: Population-based local search for protein folding simulation in the MJ energy model and cubic lattices. Computational Biology and Chemistry, 33:283-294, 2009.
        • Albrecht/Skaliotis/Steinhofel: Stochastic protein folding simulation in the three-dimensional HP-model. Computational Biology and Chemistry, 32:248–255, 2008.
        • Zahrani/Loomes/Malcolm/Albrecht: A local search heuristic for the bounded-degree minimum spanning tree problem. Engineering Optimization, 40:1115-1135, 2008.
        • Zahrani/Loomes/Malcolm/Ullah/Steinhofel/Albrecht: Genetic local search for multicast routing with pre-processing by logarithmic simulated annealing. Computers & Operations Research, 35:2049-2070, 2008.
        • Steinhofel/Skaliotis/Albrecht: Relating time complexity of protein folding simulation to approximations of folding time. Computer Physics Communications, 176:165-170, 2007.
        • Albrecht: Stochastic local search for the feature set problem, with applications to microarray data. Applied Mathematics and Computation, 183:1148-1164, 2006.
        • Albrecht: A stopping criterion for logarithmic simulated annealing. Computing, 78:55-79, 2006.
        • Zahrani/Loomes/Malcolm/Albrecht: Landscape analysis for multicast routing. Computer Communications, 30:101-116, 2006.
        • Lappas/Frank/Albrecht: A computational study on circuit size vs circuit depth. Int J on Artificial Intelligence Tools, 15:143-162, 2006.
        • Hein/Albrecht/Melzer/Steinhofel/Rogalla/Hamm/Taupitz: Computer-assisted diagnosis of focal liver lesions on CT images. Academic Radiology, 12:1205-1210, 2005.

        Languages Spoken

      • Learning &
        Teaching Interests

        • MSc in Computer Science: Module CSD4040 Advanced Topics in Computer Science - Algorithmic Biology.
        • MSc in Mathematics: Operational Research Programme.
        • BSc Studies: Final Year Project coordinator.

      • Research Outputs &
        Interests

        Key areas of research interest:

        Combinatorial Optimisation, Stochastic Local Search Algorithms, Nature-inspired Computing, Machine Learning, Biomolecular Structure Prediction, MicroRNA Pathway Analysis, Boolean Circuit Complexity, VLSI Design.

        Current Research Projects:

        • MicroRNA bindings to meta-stable RNA secondary structures.
        • Analysis of RNA energy landscapes.
        • Protein folding simulation in lattice models.
        • Microarray and sequencing data analysis.

        Software Tool Development

        MSBind:                Meta-stable RNA secondary structures analysis.
        RNAapprox:          Approximation of local minima in RNA folding landscapes.
        RandomDescent:  Random descent in attraction basins of RNA folding landscapes.

        PhD Students:

        Publication Feed

        Crispr/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function

        Lataniotis, Lazaros and Albrecht, Andreas A. and Kok, Fatma O. and Monfries, Clinton A. L. and Benedetti, Lorena and Lawson, Nathan D. and Hughes, Simon M. and Steinhofel, Kathleen and Mayr, Manuel and Zampetaki, Anna (2017) Crispr/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Scientific Reports, 7 . p. 8585. ISSN 2045-2322

        Crispr/Cas9 gene editing reveals novel tertiary constraints in clustered mirna processing

        Lataniotis, Lazaros and Albrecht, Andreas A. and Kok, Fatma and Monfries, Clinton and Benedetti, Lorena and Lawson, Nathan D. and Hughes, Simon M. and Steinhofel, Kathleen and Mayr, Manuel and Zampetaki, Anna (2017) Crispr/Cas9 gene editing reveals novel tertiary constraints in clustered mirna processing. Heart, 103 (5). A133. ISSN 1468-201X

        Random versus deterministic descent in RNA energy landscape analysis

        Day, Luke and Souki, Ouala Abdelhadi Ep and Albrecht, Andreas A. and Steinhofel, Kathleen (2016) Random versus deterministic descent in RNA energy landscape analysis. Advances in Bioinformatics, 2016 . ISSN 1687-8035

        A new heuristic method for approximating the number of local minima in partial RNA energy landscapes

        Albrecht, Andreas A. and Day, Luke and Souki, Ouala Abdelhadi Ep and Steinhofel, Kathleen (2016) A new heuristic method for approximating the number of local minima in partial RNA energy landscapes. Computational Biology and Chemistry, 60 . pp. 43-52. ISSN 1476-9271

        iRDA: a new filter towards predictive, stable, and enriched candidate genes

        Lai, Hung-Ming and Albrecht, Andreas A. and Steinhofel, Kathleen (2015) iRDA: a new filter towards predictive, stable, and enriched candidate genes. BMC Genomics, 16 . ISSN 1471-2164

        View more publications

      • Funded Research &
        Knowledge Exchange Projects

      • Engagement &
        Impact

        Member of Programme Committees:

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