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      Dr Babis Magoulas

      ROLE: SL In Life Science
      SCHOOL: Science & Technology
      DEPARTMENT: Natural Sciences
      TELEPHONE: +44 (0)20 8411 3418
      EMAIL: B.Magoulas@mdx.ac.uk
      1. Biography &
        Qualifications
      2. Learning &
        Teaching Interests
      3. Research Outputs &
        Interests
      4. Funded Research &
        Knowledge Exchange Projects
      5. Engagement &
        Impact

      • Biography &
        Qualifications

        I obtained a BSc in Biochemistry with specialisation in Medicinal Chemistry from Concordia University, Montreal, in 1984. After working for several years as a research assistant in the field of Biotechnology, I entered graduate studies in Molecular Biology and was awarded a PhD degree from Ottawa University in 1992. My PhD thesis was on the molecular evolution of genetic regulatory mechanisms.

        I then completed a five year post-doctoral training in the field of Functional Genomics at the Imperial Cancer Research Fund (now known as Cancer Research UK), where I became a Marie Curie Fellow.  In 1997, I joined the National Institute for Medical Research as a senior post-doctoral fellow in Molecular Neuroendocrinology.

        In 2000, I was appointed in a teaching and research position as a Lecturer in Neurosurgery at the School of Medicine and Dentistry in Queen Mary University of London.  I taught medical courses at different levels, undergraduate and graduate, and my research was predominantly on mechanisms of inflammation and repair in the nervous system.

        I joined Middlesex University as a Senior Lecturer in 2014. I am involved in teaching and research in Biomedicine, and particular in the development of Neuroscience programmes.

        QUALIFICATIONS

        • PhD in Molecular Biology, Ottawa University (1992)
        • BSc in Biochemistry, Concordia University (1984)

        Languages Spoken

      • Learning &
        Teaching Interests

        • Leader in the BSc Neuroscience Honours programme
        • Module Leader:
        1. Foundation Neuroscience (BMS1464)
        2. Physiological Sciences (BMS1894)
        3. Introduction to Neurology (BMS1444)
        4. Neurological Conditions (BMS2455)
        5. Neuropharmacology (BMS2415)
        6. Clinical Neurology (BMS3496)
        • Teaching in BSc and MSc Modules in Biomedical and Healthcare Sciences programmes.
        • Student supervision in Biomedical/Neuroscience topics:
        1. BSc final year lab projects/dissertations
        2. MSc and PhDs projects
        3. Visiting research fellows

      • Research Outputs &
        Interests

        RESEARCH INTERESTS

        • Neuronal Repair
        • Neuro-Inflammation
        • Cell Proliferation
        • Molecular Imaging
        • Functional Genetics

        SELECTED PUBLICATIONS

        • de Heredia, L.L.,  Magoulas, C. (2013) Lack of the transcription factor C/EBPd impairs  the intrinsic capacity of peripheral neurons for regeneration. Exp. Neurol. 239, 148-157
        • de Heredia, L. L., Gengatharan, A., Foster, J., Mather, S., Magoulas, C. (2011) Bioluminescence imaging of the brain response to acute inflammation in living C/EBP reporter mice. Neurosci.Lett. 497, 134-130
        • Malysheva, M. V., Bulycheva, T. I., Deineko, N. L., Samoilova, R. S., Kaplanskaia, I. B., Magoulas, C., Zatsepina, O. V. (2010) The levels of key nucleolar proteins in the lymphoid cells of healthy individuals and patients with lymphoproliferative diseases. Klin.Lab Diagn. 23-27
        • Gushchina, S., Leinster, V., Wu, D., Jasim, A., Demestre, M., Lopez, d. H., Michael, G. J., Barker, P. A., Richardson, P. M., Magoulas, C. (2009) Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury. Mol.Cell.Neurosci. 40, 207-216
        • Miao, T., Wu, D., Zhang, Y., Bo, X., Xiao, F., Zhang, X., Magoulas, C., Subang, M. C., Wang, P., Richardson, P. M. (2008) SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. Mol.Cell Neurosci. 37, 367-375
        • Wu, D., Zhang, Y., Bo, X., Huang, W., Xiao, F., Zhang, X., Miao, T., Magoulas, C., Subang, M. C., Richardson, P. M. (2007) Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons. Exp.Neurol. 204, 66-76
        • Le Tissier, P. R., Carmignac, D. F., Lilley, S., Sesay, A. K., Phelps, C. J., Houston, P., Mathers, K., Magoulas, C., Ogden, D., Robinson, I. C. (2005) Hypothalamic growth hormone-releasing hormone (GHRH) deficiency: targeted ablation of GHRH neurons in mice using a viral ion channel transgene. Mol.Endocrinol. 19, 1251-1262
        • Polzikov, M., Zatsepina, O., Magoulas, C. (2005) Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. Biochem.Biophys.Res.Commun. 327, 143-149
        • Liu, M., Liu, M. C., Magoulas, C., Priestley, J. V., Willmott, N. J. (2003) Versatile regulation of cytosolic Ca2+ by vanilloid receptor I in rat dorsal root ganglion neurons. J.Biol.Chem. 278, 5462-5472
        • Balthasar, N., Mery, P. F., Magoulas, C. B., Mathers, K. E., Martin, A., Mollard, P., Robinson, I. C. (2003) Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: a ventral hypothalamic network. Endocrinology 144, 2728-2740
        • Magoulas, C., McGuinness, L., Balthasar, N., Carmignac, D. F., Sesay, A. K., Mathers, K. E., Christian, H., Candeil, L., Bonnefont, X., Mollard, P., Robinson, I. C. (2000) A secreted fluorescent reporter targeted to pituitary growth hormone cells in transgenic mice. Endocrinology 141, 4681-4689
        • Magoulas, C., Fried, M. (1996) The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein. DNA Cell Biol. 15, 305-316
        • Magoulas, C., Bally-Cuif, L., Loverre-Chyurlia, A., Benkel, B., Hickey, D. (1993) A short 5'-flanking region mediates glucose repression of amylase gene expression in Drosophila melanogaster. Genetics 134, 507-515
        • Magoulas, C., Loverre-Chyurlia, A., Abukashawa, S., Bally-Cuif, L., Hickey, D. A. (1993) Functional conservation of a glucose-repressible amylase gene promoter from Drosophila virilis in Drosophila melanogaster. J.Mol.Evol. 36, 234-242

        For full publications see in PubMed, http://www.ncbi.nlm.nih.gov/pubmed/ ,

        under  'Magoulas C'.

        Publication Feed

        Involvement of the specific nucleolar protein SURF6 in regulation of proliferation and ribosome biogenesis in mouse NIH/3T3 fibroblasts

        Moraleva, Anastasiya and Magoulas, Charalambos and Polzikov, Mikhail and Hacot, Sabine and Mertani, Hichem C. and Diaz, Jean-Jacques and Zatsepina, Olga (2017) Involvement of the specific nucleolar protein SURF6 in regulation of proliferation and ribosome biogenesis in mouse NIH/3T3 fibroblasts. Cell Cycle , 16 (20). pp. 1979-1991. ISSN 1538-4101

        View more publications

      • Funded Research &
        Knowledge Exchange Projects

        Obtained over £1M research funding from grants awarded as Principal Investigator (PI) and Co-Investigator (Co-I):

        • P. Creeke, C. Magoulas (Co-I) and G. Giovannoni
          Prospects Fund, Queen Mary Innovation (QMI) and  Merz Pharmaceuticals (Germany); 2009-2012.
          Title: "Development of a novel cell based assay for measuring activity of neutralising antibodies to botulinum toxin A". 
        • C. Magoulas (PI)
          The Royal London & St Bartholomew's Charitable Foundation - PhD Studentship; 2005-2008.             
          Tile: "Analysis of the C/EBP family of inflammation-responsive transcription factors in neuronal repair".
        • C. Magoulas (PI)
          The Royal London & St Bartholomew's Charitable Foundation-Transgenic Core Facility; 2007.
          Title: "Transgenic animal models for studying the role of C/EBP family of transcription factors in neuroinflammation".
        • C. Magoulas  (PI)
          BBSRC- New Investigator Award; 2003-2007.
          Title: "Importance of NF-kB in the survival of adult peripheral neurones in response to injury".  
        • C. Magoulas (PI)
          INTAS -   Host for a visiting fellow (Mikhail Polzikov); 2004-2005.
          Title: "Transgenic inhibition of Surf-6 expression in eukaryotes".
        • C. Magoulas (PI)
          European Science Foundation – Host for a visiting fellow (Mikhail Polzikov); 2002-2003.
          Title:"Integrated Approaches for Functional Genomics: Functional analysis of Surf-6".
        • P.M.Richardson, P. Hamlyn, J.V. Priestley, C. Magoulas (Co-I), N. Willmott, V. King.  
          Corporate Action Trust; 2002-2006.
          Title: "Spinal Injury Research Project".

      • Engagement &
        Impact

        Impact

        My recent research has been towards the elucidation of key molecular factors of neuronal repair in order to be applied in therapeutic strategies for patients with damaged neuronal function in neurodegenerative diseases and trauma. 

        Public engagement

        Public presentations on Neurodegenerative Diseases.

        Memberships

        • British Neuroscience Association (BNA)
        • Federation of European Neuroscience (FENS)
        • International Brain Research Organisation (IBRO)
        • Bioscience Federation (BSF)

        u

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