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      Dr Song Wen

      Dr Song (Xuesong) Wen, MBBS,PhD
      ROLE: Senior Lecturer in Biomedical Sciences
      SCHOOL: Science & Technology
      DEPARTMENT: Natural Sciences
      TELEPHONE: +44 (0)20 8411 4931
      EMAIL: X.Wen@mdx.ac.uk
      1. Biography &
        Qualifications
      2. Learning &
        Teaching Interests
      3. Research Outputs &
        Interests
      4. Funded Research &
        Knowledge Exchange Projects
      5. Engagement &
        Impact

      • Biography &
        Qualifications

        X Wen,D Li, Y Zhang, S Liu, L Ghali, RK Iles (2012). Arsenic trioxide induces cervical cancer apoptosis but specifically targets Human Papillomavirus infected cell populations. Anti-Cancer Drugs. 23: 280–287

        B Burczynska, SA Butler, X Wen, A Shiled, RK Iles (2011). Analysis of free beta subunit of hCG secretion by common epithelial cancer cell lines.39th Congress of the International Society of Oncology and Biomarkers, October 2011, Florence, Italy.

        X Wen, D Li, AJ Tozer, SM Docherty, RK Iles(2010). Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles. Reproductive Biology and Endocrinology, 8:117.

        Xuesong Wen, Dong Li, Lucy Ghali, and Ray K Iles. (2010) Ectopic HCG beta may induce epithelialmensenchymal transition on human kera tinocytes in vitro and this could promote tumour progression and invasion. Tumour Biology, 31 (S44). ISSN 1010-4283

        X. Wen, D Perrett, SM Docherty, AJ Tozer, RK Iles (2009). High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle.Metabolism. 59:1145-1155.

        X. Wen, D Perrett, P. Patel, NJ Li, SM Docherty, AJ Tozer, RK Iles (2009). Capillary electrophoresis of human follicular fluid. J of Chromatography B. 877: 3946-52

        D Li, X Wen, L Ghali , FM Al-Shalabi, SM Docherty, Patricia Purkis, Ray K Iles (2008).hCGbexpression by cervical squamous carcinoma - in vivo histological association with tumor invasion and apoptosis. Histopathology53: 147-155.

        X Wen, AJ Tozer, D Li, SM Docherty, T Al-Sharwaf and RK Iles (2008). Human granulosa-lutein cell in vitro production of progesterone, inhibin-A, inhibin-B and activin-A are dependent on follicular size and not the presence of the oocyte. Fertility Sterility89:1406-13.

        X Wen, L Ghali, D Li, N Li, R Iles. Ectopic hCG beta may induce Epithelial-Mensenchymal Transition on Human Keratinocytes in vitro and this could promote tumour progression and invasion. 38th Congress of the International Society of Oncology and Biomarkers, September 3rd-8th, 2010, Munich, Germany. Invited oral presentation.

        X Wen, D Li, L Ghali, A Shiled, RK Iles. Human Chorionic Gonadotrophin beta expression and growth effects on Breast and Prostate cancer cell lines. 2nd International Conference on Gonadotrophin & Receptors, July 6-9th, 2008, Herdfordshire, UK.

        A Shiled, X Wen, M Naase, F Hills, S. Butler, RK Iles. Fetal Calf Serum effects on the secretion of Human Chorionic Gonadotrophin beta by bladder cancer cell lines in vitro. 2nd International Conference on Gonadotrophin & Receptors, July 6-9th, 2008, Herdfordshire, UK.

        X Wen, AJ Tozer, SA Butler, CM Bell, SM Docherty and RK Iles (2006). Follicular Fluid levels of Inhibin A, inhibin B and activin A levels reflect changes in follicle size but are not independent markers of oocyte ability to fertilize. Fertility Sterility 2006, 8(56): 1723-9.

        D Li,XS Wen, SM Docherty, L Ghali, RK Iles. The beta subunit of hCG may have a role in anti-apoptosis, and in tumour invasion of cervical squamous carcinoma. 1st International conference of gonadotrophins & receptors (ICGR), April 13-17th, 2005, Athens, Georgia, USA.

        Tozer AJ, Iles RK, Iammarrone E, Nica RA, Gillott CM, Xuesong WEN, Al-Shawaf T, Grudzinskas JG (2004). Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF. Hum Reprod 19(11):2561-8.

        XS Wen, AJ Tozer, SA Butler, RK Iles. Biochemical evidence for follicular maturation (1): Changes of inhibins and activin A levels in follicular fluid from matched follicles; Biochemical evidence for follicular maturation (2): Production of progesterone, inhibins and activin by granulose cells from size-matched follicles. 23rd Joint Meeting of the British Endocrine Societies(BES), March 22-24, 2004, Brighton, UK.

        XS Wen,SA Butler, RK Iles. Anti-hCG vaccine as a promising contraceptive method. Invited oral presentation for 3rd International Conference for the development of new technology , 22th-28st September 2003, Da Lian, China.

        XS Wen, SA Butler, RK Iles. Changes of inhibin A, inhibin B, activin A levels in follicular fluid from individual follicles. International Workshop on Inhibin, Activin and Follistatin. , July 3-4th, 2003, Sienna, Italy.

        Languages spoken

        I am fluent in Mandarin other than English.


        Languages Spoken

      • Learning &
        Teaching Interests

        1. Reproductive physiology

        2. Chemistry

        3. Cellular pathology

        4. Immunohistochemical techniques

      • Research Outputs &
        Interests

        1. Assisted Reproductive technology

        2. Cancer biology

        3. hCG beta and epithelial cancers

        4. Human papillomavirus associated cancers

        5. Nanotechnology in drug delivery

        Publication Feed

        Optimisation of folate-mediated liposomal encapsulated arsenic trioxide for treating HPV-positive cervical cancer cells in vitro

        Akhtar, Anam and Ghali, Lucy and Wang, Scarlet and Bell, Celia M. and Li, Dong and Wen, Xuesong (2019) Optimisation of folate-mediated liposomal encapsulated arsenic trioxide for treating HPV-positive cervical cancer cells in vitro. International Journal of Molecular Sciences, 20 (9). ISSN 1422-0067

        Effective delivery of arsenic trioxide to HPV-positive cervical cancer cells using optimised liposomes: a size and charge study

        Akhtar, Anam and Wang, Scarlet Xiaoyan and Ghali, Lucy and Bell, Celia M. and Wen, Xuesong (2018) Effective delivery of arsenic trioxide to HPV-positive cervical cancer cells using optimised liposomes: a size and charge study. International Journal of Molecular Sciences, 19 (4). ISSN 1422-0067

        Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation

        Wang, Scarlet Xiaoyan and Wen, Xuesong and Bell, Celia M. and Appiah, Sandra S. (2018) Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation. Molecular Medicine Reports, 17 (3). pp. 4524-4530. ISSN 1791-2997

        α-Mangostin, singly and in combination with Doxorubicin, as pro-apoptotic agents and protein kinase inhibitors In the AML cell line, Molm13

        Osemeke, Cynthia and Garelick, Hemda and Wen, Xuesong and Appiah, Sandra S. (2018) α-Mangostin, singly and in combination with Doxorubicin, as pro-apoptotic agents and protein kinase inhibitors In the AML cell line, Molm13. In: EACR Conference Series: A matter of Life or Death. from Basic cell Death Mechanism to Novel cancer Treatment, 1th-3rd Feb. 2018, Amstardam, Netherlands.

        Doxorubicin combined with Alpha Mangostin as pro-apoptotic agents and as potential kinase inhibitors of acute Myeloid Leukaemia

        Osemeke, Cynthia and Garelick, Hemda and Wen, Xuesong and Appiah, Sandra S. (2017) Doxorubicin combined with Alpha Mangostin as pro-apoptotic agents and as potential kinase inhibitors of acute Myeloid Leukaemia. In: 2017 NCRI Cancer Conference, 5-8 Nov 2017, Liverpool, UK.

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      • Funded Research &
        Knowledge Exchange Projects

      • Engagement &
        Impact

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