Darshna completed her PhD at Imperial College, London investigating the role of human monocytes in a model of cellular inflammation. She has worked at the Hammersmith Hospital and Institute of Cancer Research at the Royal Marsden Hospital in diagnostics and reserach.
Her research interests include the use of chemical derivatives or alternative medications in treating infectious diseases, combatting cancer and inflammation.
Yagnik DR, Evans BJ, Florey O, Mason J etal 2004. TGFbeta1 implicated in the mechanism by which MSU crystal stimulated macrophages resolve MSU crystal induced inflammation. 2004 Arthritis and Rheumatism. July ; 50 (7): 2273-80
Stefanou C, Asimakopoulus, G, Yagnik DR, Haskard, DO et al 2004 Monocyte FC gamma expression in patients undergoing coronary artery bypass grafting. Journal of Thoracic Surgery. 77(3) ;951-55
Landis RC, Yagnik DR etal 2002 Safe disposal of monosodium monohydrate crystal by macrphages. Arthritis and Rheumatism.Vol46 (11) 3026-33
Yagnik DR, Hillyer, P et al 2000 Non-inflammatory phagocytosis of monosodium monohydrate urate crysytals by mouse macrophages, implications for the control of joint inflammation in gout.. Arthritis and Rheumatism. Vol 43 (8) 1779-89
Teaching on degrees
BSc HONS Biomedical Science,
MSc Medical Immunology
Research outputs focus on the molecular mechanisms by which inflammation is resolved in arthritis such as gout using a model of celluar inflammation.
The applications of apple cider vinegar as an anti microbial product against common pathogens.
The use of plant based compounds in the treatment of cancer.
Yagnik, Darshna and Ward, Malcolm and Shah, Ajit J. (2021) Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli. Scientific Reports , 11 (1). pp. 1-7. ISSN 2045-2322
Yagnik, Darshna (2021) Coenzyme Q10 and vitamin D interventions could ameliorate COVID-19 related cellular bioenergetic dysfunction and cytokine storms. Journal of Immunological Sciences , 5 (3). pp. 1-6. ISSN 2578-3009
Loizidou, Erika and Yagnik, Darshna and Szalecka, Monika and Nguyen, Dao Thanh Thuong (2019) The potential use of microneedles as an alternative method for skin cancer treatment. In: The World Congress on Advanced Treatments and Technologies in Skin Cancer (Skin-Cancer2019), 4-5 Apr 2019, Vienna, Austria.
Yagnik, Darshna and Serafin, Vlad and Shah, Ajit J. (2018) Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression. Scientific Reports , 8 (1). ISSN 2045-2322
Yagnik, Darshna and Hills, Frank (2018) Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone. Molecular Medicine Reports , 18 (3). pp. 3506-3512. ISSN 1791-2997
Immunology Editor at SR
Advisory: Advised on disinfection, face masking, hand sanitisation and vaccine development against SARS-COV-2 during the pandemic to
New York Times.