Prof Ajit Shah

My research is driven by a commitment to translating analytical science into clinical solutions. A key focus of my work is the development of innovative mass spectrometry-based assays and biosensors to improve disease diagnosis and patient monitoring. For example, i have been involved in the development of a biosensor for real-time antibiotic detection, currently under validation, which aims to enable bedside monitoring of antibiotic levels and enhance precision in antimicrobial therapy.

Building on this translational foundation, I apply advanced proteomic and metabolomic approaches—using ultra high-pressure liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS)—to identify and quantify disease biomarkers. My research aims to bridge discovery and clinical utility by integrating global proteomics and metabolomics data with quantitative mass spectrometry.

I also specialise in developing high-throughput, quantitative MS-based methods for existing biomarkers to improve detection accuracy and clinical relevance. One such example is the development of a quantitative assay for Anti-Müllerian Hormone (AMH), which supports the diagnosis of infertility in women.

Another important area of my research focuses on the analysis of glycosaminoglycans, including heparin/heparan sulphate, chondroitin sulphate, and dermatan sulphate. Through MS-based quantitation, we have identified polysaccharide subunits that can predict preeclampsia before the onset of clinical symptoms, demonstrating the potential of these molecules as early diagnostic biomarkers.

In addition, I investigate the mechanisms of antimicrobial resistance using proteomic strategies to uncover novel therapeutic targets with the aim of helping the development of next-generation antimicrobial agents.

These research themes reflect my overarching aim: to advance bioanalytical science for meaningful clinical impact, enabling earlier disease detection, improved diagnostics, and more precise patient care.

I am the module leader for one undergraduate module, CHE3786 – Medical Pharmaceutical Bioanalytical Techniques, and a large core postgraduate module with around 72 students, BMS4977 – Advanced Bioanalytical Techniques. I integrate real-world experience into my teaching by providing live demonstrations of analytical instruments during lectures. In addition, I serve as the Director of Studies for two PhD students and co-supervise six others.