Identifying Fibroblast Growth Factor Receptor 3 as a Mediator of Periosteal Osteochondral Differentiation through the Construction of microRNA-Based Interaction Networks

Wells, L. M., Roberts, H. C., Luyten, F. P. and Roberts, S. J Identifying Fibroblast Growth Factor Receptor 3 as a Mediator of Periosteal Osteochondral Differentiation through the Construction of microRNA-Based Interaction Networks. Biology.
 

A machine learning‑based image segmentation method to quantify in vitro osteoclast culture endpoints

Davies, B.K., Hibbert, A.P., Roberts, S.J., Roberts, HC., Tickner, J.C., Holdsworth, G., Arnett, T.R. and Orriss, I.R. 2023. A machine learning‑based image segmentation method to quantify in vitro osteoclast culture endpoints. Calcified Tissue International and Musculoskeletal Research. 113 (4), p. 437–448.
 

Establishment and characterization of single and triple‐agent resistant osteosarcoma cell lines

Low, K., Hills, F., Roberts, HC. and Stordal, B. 2023. Establishment and characterization of single and triple‐agent resistant osteosarcoma cell lines. Advanced Biology. 7 (2). https://doi.org/10.1002/adbi.202200194
 

Intentionality for inclusivity - the journey at Middlesex University

Roberts, H.C, Punev, I., Allardyce, D., Kyprianou, A., Appiah, S., Megeney, A., Calin, A., Gallacher, D. and Mill, R. 2022. Intentionality for inclusivity - the journey at Middlesex University. McGraw Hill.
 

Decellularised cartilage ECM culture coatings drive rapid and robust chondrogenic differentiation of human periosteal cells

Vas, W., Shah, M., Roberts, HC. and Roberts, S. 2022. Decellularised cartilage ECM culture coatings drive rapid and robust chondrogenic differentiation of human periosteal cells. Bioengineering. 9 (5), pp. 11. https://doi.org/10.3390/bioengineering9050203
 

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, D., Roberts, H. and et al. 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 17 (1), pp. 1-382. https://doi.org/10.1080/15548627.2020.1797280

Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair

Roberts, H. Mapping human serum–induced gene networks as a basis for the creation of biomimetic periosteum for bone repair. Cytotherapy. https://doi.org/10.1016/j.jcyt.2020.03.434

The combination of curcumin and doxorubicin shows a selective cytotoxic effect on acute myeloid leukaemia cell line

Hasan, N., Roberts, H., Ghali, L. and Appiah, S. 2018. The combination of curcumin and doxorubicin shows a selective cytotoxic effect on acute myeloid leukaemia cell line. NCRI Cancer Conference (2018). Glasgow, Scotland 04 - 06 Nov 2018

MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism?

Jones, T., Torrance, H., Roberts, H., Brohi, K., Barnes, M., Knight, J., Hinds, C., Ackland, G. and O'Dwyer, M. 2018. MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism? British Journal of Anaesthesia Research Forum. Royal College of Anaesthetists, London 30 - 31 May 2018 Elsevier. pp. e23-e24 https://doi.org/10.1016/j.bja.2018.05.027

Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways.

Roberts, H. Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways. Annals of surgery. https://doi.org/10.1097/sla.0000000000001484

Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5.

Roberts, H. Systemic Inflammatory Response Syndrome After Major Abdominal Surgery Predicted by Early Upregulation of TLR4 and TLR5. Annals of surgery. https://doi.org/10.1097/sla.0000000000001248

The perioperative immune response.

Roberts, H. The perioperative immune response. Current opinion in critical care. https://doi.org/10.1097/mcc.0000000000000213

Changes in gene expression following trauma are related to the age of transfused packed red blood cells.

Roberts, H. Changes in gene expression following trauma are related to the age of transfused packed red blood cells. The journal of trauma and acute care surgery. https://doi.org/10.1097/ta.0000000000000534

T-helper cell polarisation following severe polytrauma.

Torrance, Hdt, Brohi, K, Warnes, G, Owen, H C, Hinds, C J, Pennington, D J, O'Dwyer, M J and Roberts, H. T-helper cell polarisation following severe polytrauma. Intensive Care Medicine Experimental. https://doi.org/10.1186/2197-425x-3-s1-a848

The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients.

Owen, H C, Torrance, Hdt, Barnes, M R, Brohi, K, Knight, J C, Hinds, C J, O'Dwyer, M J and Roberts, H. The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients. Intensive Care Medicine Experimental. https://doi.org/10.1186/2197-425x-3-s1-a35

Association Between Early Postoperatively Elevated TLR-4 & TLR-5 Gene Expression and Late Nosocomial Infection in Elective High-Risk Hepato-Pancreato-Biliary (HPB) Surgery

Pirmadjid, N., Torrance, H. D. T., Owen, H. C., Alazawi, W., O'Dwyer, M. J. and Roberts, H. Association Between Early Postoperatively Elevated TLR-4 & TLR-5 Gene Expression and Late Nosocomial Infection in Elective High-Risk Hepato-Pancreato-Biliary (HPB) Surgery. British Journal of Surgery.

Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma

Owen, Helen C., Torrance, Hew D. T., Jones, Timothy F., Pearse, Rupert M., Hinds, Charles J., Brohi, Karim, O'Dwyer, Michael J. and Roberts, H. Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma. Journal of Trauma and Acute Care Surgery. https://doi.org/10.1097/ta.0000000000000850

Hypermethylation of CpG Islands and Shores around Specific MicroRNAs and Mirtrons Is Associated with the Phenotype and Presence of Bladder Cancer

Dudziec, Ewa, Miah, Saiful, Choudhry, Hani M. Z., Owen, Helen C., Blizard, Sheila, Glover, Maggie, Hamdy, Freddie C., Catto, James W. F. and Roberts, H. Hypermethylation of CpG Islands and Shores around Specific MicroRNAs and Mirtrons Is Associated with the Phenotype and Presence of Bladder Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-10-2017

LOW FREQUENCY OF EPIGENETIC EVENTS IN UROTHELIAL TUMOURS FROM YOUNG PATIENTS

Catto, J. W. F., Owen, H. C., Giedl, J., Wild, P. J., Fine, S. W., Epstein, J. I., Humphrey, P. A., Dehner, L. P., Amin, M. B., Blaszyk, H., Hughes, D., Hartmann, A., Stoehr, R. and Roberts, H. LOW FREQUENCY OF EPIGENETIC EVENTS IN UROTHELIAL TUMOURS FROM YOUNG PATIENTS. European Urology Supplements. https://doi.org/10.1016/s1569-9056(10)60798-1

Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer

Catto, James W. F., Miah, Saiful, Owen, Helen C., Bryant, Helen, Myers, Katie, Dudziec, Ewa, Larre, Stephane, Milo, Marta, Rehman, Ishtiaq, Rosario, Derek J., Di Martino, Erica, Knowles, Margaret A., Meuth, Mark, Harris, Adrian L., Hamdy, Freddie C. and Roberts, H. Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer. Cancer Research. https://doi.org/10.1158/0008-5472.can-09-0744

Identification and functional involvement of lipocalin 2 in glucocorticoid-induced growth retardation

Owen, H. C., Ahmed, S. F., Farquharson, C. and Roberts, H. Identification and functional involvement of lipocalin 2 in glucocorticoid-induced growth retardation. Journal of Bone and Mineral Research.

The role of P21CIP1/WAF1 in glucocorticoid induced growth retardation

Owen, H. C., Ahmed, S. F., Farquharson, C. and Roberts, H. The role of P21CIP1/WAF1 in glucocorticoid induced growth retardation. Journal of Bone and Mineral Research.

Identification of lipocalin 2, a novel glucocorticoid responsive gene in growth plate chondrocytes

Owen, H. C., Ahmed, S. F., Farquharson, C. and Roberts, H. Identification of lipocalin 2, a novel glucocorticoid responsive gene in growth plate chondrocytes. Journal of Bone and Mineral Research.

Glucocorticoids stimulate p21 expression in growth plate chondrocytes

Owen, HC, Ahmed, SF, Farquharson, C and Roberts, H. Glucocorticoids stimulate p21 expression in growth plate chondrocytes. Journal of Bone and Mineral Research.

Glucocorticoids induce lipocalin 2 gene expression in growth plate chondrocytes.

Owen, H. C., Ahmed, S. F., Farquharson, C. and Roberts, H. Glucocorticoids induce lipocalin 2 gene expression in growth plate chondrocytes. Journal of Bone and Mineral Research.

The role of the 11 beta HSD shuttle in modulating the effects of proinflammatory cytokines on the growth plate.

MacRae, V. E., Owen, H. C., Ahmed, S. F., Farquharson, C. and Roberts, H. The role of the 11 beta HSD shuttle in modulating the effects of proinflammatory cytokines on the growth plate. Journal of Bone and Mineral Research.