Following my PhD and postdoctoral appointments I joined GlaxosmithKline as a Senior Scientist within Drug Discovery. Over 20 years I held various positions within Drug Discovery that include a post as Team Leader at Principal Scientist level. During my tenure at GSK I received a number of science awards and in 2008 was awarded an exceptional science award for my work in area of Neuroscience.

In 2010 I joined Middlesex University to take on a post as Reader in Bioanalytical Science. The position involves teaching, supervision, research and consultancy work. The research areas that I am involved in are development of platform for metabolomics, application of analytical techniques like mass spectrometry for measurement of molecules in biological matrices and development/improvement of analytical instruments in collaboration with instrument manufacturers.

Publications

Shah, A. J.; Adlard, M. W. Trace level measurement of b-lactam antibiotics and biosynthetic intermediates following precolumn derivatisation with 9-fluoroenylmethylcholorformate. J. Chromatog. (1988) 325-336.

Shah, A. J.; Adlard, M. W.; Holt, G. Quantitation of natural penicillins in fermentation media by high performance liquid chromatography using precolumn derivatisation with 1-hydroxybenzo-triazole. Analyst (1988) 1197-200.

Shah, A. J.; Adlard, M. W.; Stride, J. D. A sensitive assay for clavulanic acid and sulbactam in biological fluids by high performance liquid chromatography and precolumn derivatisation. J. Pharm. Biomed. Anal. (1990) 437-443.

Shah, A. J.; Tilburn, J.; Adlard, M. W.; Arst, H. N., Jr. pH Regulation of penicillin production in Aspergillus nidulans.FEMS Microbiol. Letts. (1991) 209-212.

Shah, A. J.; Younie, D. A.; Adlard, M. W.; Evans, C. S. High-performance liquid chromatography of non-protein amino acids produced in Acacia seeds. Phytochem. Anal. (1992) 20-25.

Evans, C. S.; Shah, A. J.; Adlard, M.W.; Arce, M. L. R. Non-protein amino acids in seeds of neotropical species of Acacia. Phytochemistry (1992) 123-126.

Shah A.J; Orford C D.; Adlard M. W. Derivatisation methods for trace-level quantification of b-lactam antibiotics. LC-GC (1993).

Shah, A. J.; Younie, D. A.; Adlard, M. W.; Evans, C. S. Evolutionary trends within genus Acacia based on the accumulation of non-protein amino acids in seeds. Advance in legume Systematics 5 (1994).

Shah, A.; de Biasi, V.; Camilleri, P. Development of a spectrophotometric method for the measurement of thiols at trace levels. Anal. Proceedings (1995) 149-153.

Shah, A; Rahman S.S; Biasi V. de; Camilleri P; Development of a colorimetric method for the detection of amines bound to solid support. (1995) 149-153.

Hagan, J. J.; Leslie, R. A.; Patel, S.; Evans, M. L.; Wattam, T. A.; Holmes, S.; Benham, C. D.; Taylor, S. G.; Routledge, C.; Hemmati, P.; Munton, R. P.; Ashmeade, T. E.; Shah, A. J.; Hatcher, J. P.; Hatcher, P. D.; Jones, D. N. C.; Smith, M. I.; Piper, D. C.; Hunter, A. J.; Porter, R. A.; Upton, N. CNS Localisation and Effects of Orexin-A.Proceedings of the National Academy of Sciences of the United States of America (1999) 10911-10916.

Shah, A. J.; de Biasi, V.; Taylor, S. G.; Roberts, C.; Hemmati, P.; Munton, R.; West, A.; Routledge, C.; Camilleri, P. Development of a protocol for the automated analysis of amino acids in brain tissue samples and microdialysates. J. Chrom. B: Biomedical Sciences and Applications (1999) 133-140

Hadley M; Gilges M; Senior J; Shah A; Camilleri; Capillary Electrophoresis in the pharmaceutical industry:applications in discovery and chemical development.J. Chrom. B: Biomedical Sciences and Applications (1999) 177-188.

Hemmati, P.; Shilliam, C. S.; Hughes, Z. A.; Shah, A. J.; Roberts, J. C.; Atkins, A. R.; Hunter, A. J.; Heidbreder, C. A. In vivo characterization of basal chemoneuroanatomical markers for amino acids in the shell and core subterritories of the nucleus accumbens. Neurochemistry International (2001) 199-208.

Heidbreder, C. A.; Lacroix, L.; Atkins, A. R.; Organ, A. J.; Murray, S.; West, A.; Shah, A. J. Development and application of a sensitive high performance ion-exchange chromatography method for the simultaneous measurement of dopamine, 5-hydroxytryptamine and norepinephrine in microdialysates from the rat brain. Journal of Neuroscience Methods (2001) 135-144.

Senior J; Shah A; Monteux C; Biasi V De; The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines. J. Pharm. Biomed. Anal. (2001) 843-848.

Tolson, D.; Organ, A.; Shah, A. Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries. Rapid Comm. Mass Spectro. (2001) 1244-1249.

Heidbreder, C. A.; Foxton, R.; Cilia, J.; Hughes, Z. A.; Shah, A. J.; Atkins, A.; Hunter, A. J.; Hagan, J. J.; Jones, Declan N. C. Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation. Psychopharmacology (2001) 338-351

Hows, M, E. P.; Organ, A. J.; Murray, S.; Dawson, L. A.; Foxton, R.; Heidbreder, C.; Hughes, Z. A.; Lacroix, L.; Shah, A. J. High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates. J. Neuroscience Methods (2002) 33-39.

Shah, A. J.; Crespi, F.; Heidbreder, C. Amino acid neurotransmitters: separation approaches and diagnostic value. J. Chromatog. B: Analytical Technologies in the Biomedical and Life Sciences (2002) 151-163.

Lacroix, L. P.; Hows, M. E. P.; Shah, A. J.; Hagan, J. J.; Heidbreder, C. A. Selective Antagonism at Dopamine D3 Receptors Enhances Monoaminergic and Cholinergic Neurotransmission in the Rat Anterior Cingulate Cortex. Neuropsychopharmacology (2003) 839-849.

Dawson, L. A.; Organ, A. J.; Winter, P.; Lacroix, L. P.; Shilliam, C. S.; Heidbreder, C.; Shah, A. J. Rapid high-throughput assay for the measurement of amino acids from microdialysates and brain tissue using monolithic C18-bonded reversed-phase columns. J. Chromatog. B: Analytical Technologies in the Biomedical and Life Sciences (2004) 235-241.

Hows, M. E. P.; Lacroix, L.; Heidbreder, C.; Organ, A.J.; Shah, A. J. High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples. J. Neuroscience Methods (2004) 123-132.

Hows, M. E. P.; Ashmeade, T. E.; Billinton, A.; Perren, M. J.; Austin, A. A.; Virley, D. J.; Organ, A. J.; Shah, A. J. High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates. J. of Neuroscience Methods (2004) 221-226.

Shah, A. J.; De la Flor, R.; Atkins, A.; Dawson, L. A. Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N- acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts. J. Chromatogr. B: Analytical Technologies in the Biomedical and Life Sciences (2008) 153-158.

Bianchi, M.; Shah A.J.; Fone, K.C.; Atkins, A.R.; Dawson, L.A.; Heidbreder, C.A.; Hows, M.E.; Hagan, J.J.; Marsden, C.A. Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus. Synapse (2009) 63 359-364.

Bianchi, M.; Fone, K.C.F.; Shah, A.J.; Atkins, A.R.; Dawson, L.A.; Heidbreder, C.A.; Hows, M.E.; Hagan, J.J.; Marsden, C.A.; (2009); Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats; European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology; 19; 778-790.

Fricker A-C, Selina M.H., de la Flor R., Shah A.J., Woolley M, Dawson L.A., Kew J. N.C. Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR. Neuropharmacology (2009) 56 1060-1067.

Di Daniel E.; Mok, M.H.S.; Mead, E.; Mutinelli, C.; Zambello, E.; Caberlotto, L.L.; Pell, T.J.; Langmead, C.J.; Shah, A.J.; Duddy, G.; Kew, J.N.C.; Maycox, P.R.; (2009); Evaluation of expression and function of the H⁺/myo-inositol transporter HMIT; BMC Cell Biology; 10; 1-12.

Trivedi, D; Jones, H, Shah, A.J., Iles, R.K; (2012) Development of zwitterionic hydrophilic liquid chromatography (ZIC-HILIC-MS) metabolomics method for shotgun analysis of human urine; 3; 144-156.

Serafim V., Shah A., Puiu M., Andreescu N., Coricovac D., Nosyrev A., Spandidos D.A., Tsatsakis A. M., Dehelean C., Pinzaru L. (2017) Classification of cancer cell lines using matrix-assisted laser desorption/ionization time‑of‑flight mass spectrometry and statistical analysis. Int. J. Mol. Med. 40(4) 1096-1104.

Shah, A J.; Shah, H N. (2017) Determination of Antimicrobial Resistance using Tandem Mass Spectrometry In: The Triumph of MALDI-TOF Mass Spectrometry and New Developments in Tandem Mass Spectrometry for Clinical Microbiology, 2^nd London, Wiley.

Olkun A.; Shah, A J.; Shah, H N. (2017) Processing MALDI-TOF MS Data through BioNumerics for delineating intraspecies diversity In: The Triumph of MALDI-TOF Mass Spectrometry and New Developments in Tandem Mass Spectrometry for Clinical Microbiology", 2nd London, Wiley.

Serafim V.; Shah H.N.; Hennessy N.;  Allen D.J.; Ring C.; Munoz L.P.; Shah A.J.; (2017) Mass Spectrometry Application in Viral Analysis In: The Triumph of MALDI-TOF Mass Spectrometry and New Developments in Tandem Mass Spectrometry for Clinical Microbiology",  2^nd London, Wiley.

Serafim V., Ring C., Pantoja, L, Shah H, Shah A; (2017) Rapid Identification of E. coliBacteriophages using Mass Spectrometry. Journal of Proteomics and Enzymology. 2017, 5:2.

Antia I.U. , Yagnik D.R., Shah A.J., Hills F.A. (2017) Measurement of heparan sulphate disaccharides in biological samples using pre-column derivatisation with UPLC-MS and single ion monitoring. Anal. Biochem. 530, 17-30.

Wang S.X., Acha D., Shah

Wang S.X., Acha D^., Shah A.J., Hills F., Roitt I., Demosthenous A., Bayford R.H. (2016) Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor. Biosens Bioelectron. S0956-5663(16) 31109-5.

Languages spoken

Gujarati

Hindi